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Major Areas of Immune Dysfunction in AI Disease NF-kB activation and dampening Glutathione recycling system Barrier system integrity TH-1 and TH-2 polar shifts TH-3 or regulatory T-cell activation TH-17 activation and dampening Nitric oxide isomer expressions NF-kB Activation and Dampening An increasing number of studies indicate that a protein complex known as NF-kB plays an important role in controlling the expression of genes related to the development of autoimmunity